期刊
TRANSLATIONAL RESEARCH
卷 231, 期 -, 页码 1-12出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trsl.2020.12.004
关键词
-
资金
- Center of Drug Research and development (CDRD), Faculty of Pharmacy, The British University in Egypt (BUE)
The study revealed that SerpinB1 levels were significantly lower in T2DM patients and negatively correlated with α-cell function, glycemic control, and lipid profile parameters. Higher serum SerpinB1 levels were associated with lower susceptibility for T2DM.
Diabetes mellitus (DM) is a devastating metabolic disease. Recently, the cross-talk between insulin-secreting-a-cells and various organs has sparked much interest. SerpinB1 emerged as a novel hepatokine inducing a-cell proliferation. However, its role in type-2-DM (T2DM) patients has not been adequately studied. This study was designed to investigate its circulating levels in subjects with/without T2DM, and to study its association with a-cell function, as well as various glycemic-control and lipid-profile parameters. Anthropometric data and biochemical markers including fasting plasma glucose (FPG), HbA1C % and lipid profile parameters were measured in 55 T2DM patients, as well as 30 healthy nondiabetic subjects. Serum serpinB1, insulin and C-peptide levels were measured by ELISA. The homeostasis model assessment of both a-cell function (HOMA2-a%) and insulin resistance (HOMA-IR) were calculated. SerpinB1 levels were found to be significantly lower in T2DM patients 0.7 (0.2-12.4) ng/mL, compared to nondiabetic subjects 1.2 (0.94-24) ng/mL, P < 0.001, regardless of glycemic control, obesity, or insulin resistance. Additionally, serpinB1 levels were found to be positively associated with C-peptide, HOMA2-a% in all subjects; and BMI only in non-DM subjects; while negatively associated with FPG, HbA1C% and lipid-profile parameters. Higher serum serpinB1 levels were found to be associated with lower susceptibility for T2DM. Conclusively, serpinB1 is associated with various aspects of a-cell dysfunction, glycemic-control, and dyslipidemia with a possible role in a-cell compensation in obese nondiabetic subjects. The results of the current study shed lights on potential novel roles of serpinB1 in T2DM besides its action as an inducer for a-cell proliferation. (Translational Research 2021; 231:1-12)
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