期刊
TRANSLATIONAL ONCOLOGY
卷 14, 期 1, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2020.100974
关键词
Small noncoding RNA; Renal cell carcinoma; MicroRNA; Piwi-interacting RNA; TRNA-derived small RNA
类别
资金
- Joint construction project of Zhejiang Province and Ministry [2020388200]
- Key R&D plan of Zhejiang Province [2019C03089]
- National Natural Science Foundation of China [81672520, 81870484, 81773789]
- Zhejiang Provincial Natural Science Foundation of China [LY17H160020]
- Zhejiang Medical and Health Plan Project [2019ZD007]
Small noncoding RNAs, including miRNAs, piRNAs, and tsRNAs, play critical roles in renal cell carcinoma, showing potential value in diagnosis and treatment.
Noncoding RNAs are transcribed in the most regions of the human genome, divided into small noncoding RNAs (less than 200 nt) and long noncoding RNAs (more than 200 nt) according to their size. Compelling evidences suggest that small noncoding RNAs play critical roles in tumorigenesis and tumor progression, especially in renal cell carcinoma. MiRNA, the most famous small noncoding RNA, has been comprehensively explored for its fundamental role in cancer. And several miRNA-based therapeutic strategies have been applied to several ongoing clinical trials. However, piRNAs and tsRNAs, have not received as much research attention, because of several technological limitations. Nevertheless, some studies have revealed the presence of aberration of piRNAs and tsRNAs in renal cell carcinoma, highlighting a potentially novel mechanism for tumor onset and progression. In this review, we provide an overview of three classes of small noncoding RNA: miRNAs, piRNAs and tsRNAs, that have been reported dysregulation in renal cell carcinoma and have the potential for advancing diagnosis, prognosis and therapeutic applications of this disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据