期刊
TRANSLATIONAL ONCOLOGY
卷 14, 期 1, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2020.100932
关键词
Circulating tumor cells; Circulating tumor microemboli; Colon adenocarcinoma; Platelet-to-lymphocyte ratio; Liquid biopsy
类别
资金
- Sao Paulo Research Foundation (FAPESP) [2016/18786-9]
- Labour Public Ministry [TAC-MP-PAJ 000968.2012.10.000/0]
- FAPESP [2015/16952-6, 2019/18100-8]
- Brazilian National Council for Scientific and Technological Development (CNPq) [190144/2017-3]
The study investigated the importance of CTCs, CTM, PLR, and NLR in non-metastatic colon cancer progression, revealing that CTCs and PLR analysis may be clinically useful for colon cancer management and risk stratification. High PLR levels were associated with high-risk cancer stages, while NLR was not significantly linked to disease stage or recurrence.
Colorectal cancer is a common and often deadly cancer. Circulating tumor cells (CTCs) have been implicated as a potentially valuable prognosis factor. The detection of circulating tumor microemboli (CTM) and of simple blood component parameters that reflect inflammatory status, such as the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR), may provide information about tumor progression. The aim of this study was to explore the importance of CTCs, CTM, PLR, and NLR prospectively in non-metastatic colon cancer progression. CTCs were enriched using ISET (R) (Isolation by SizE of Tumor cells) and identified by immunocytochemical exclusion of leukocytes. We evaluated CTCs and blood cell parameters in a cohort of 69 stage I-III colon cancer patients (52.2% men; median age, 61 years; age range, 19-87 years) at a baseline timepoint prior to resection surgery. The median of CTC levels at baseline was 20 cells/8 mL (0-94) and higher levels were associated with CTM presence (p = 0.02). CTM were found in 18 (26.1%) patients. Of 18 stage I patients, 33.3% had CTM and of 51 stages II or III patients, 13.7% had CTM (p = 0.08). Patients with a high PLR (>124) were mostly (75.6%) diagnosed with high-risk stages II/III cancer (stages I/low-risk II, 24.4%; p = 0.014). All 8 patients that had disease recurrence during follow-up had a high PLR (p = 0.02 vs. low PLR). NLR was not significantly associated with disease stage or recurrence. The present results indicate that CTCs and PLR analyses may be clinically useful for colon cancer management and risk stratification.
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