期刊
TRANSFUSION AND APHERESIS SCIENCE
卷 60, 期 2, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.transci.2021.103052
关键词
Plerixafor; Healthy donor; Mobilization; CD34+cells
类别
Addition of plerixafor after G-CSF mobilization failure in HRDs allowed collecting higher number of CD34+ cells compared to steady-state mobilization.
Plerixafor (Mozobil, Sanofi) is approved for using in patients with lymphoma and multiple myeloma when steady-state mobilization strategies fail. Although off-label use of plerixafor in healthy related donors (HRD) is known, limited data are available and no recommendations exist to guide its use in this setting. With the aim of collecting data from HRDs who received plerixafor in our country, we designed an observational case series study within the Spanish Group of Hematopoietic Transplant and Cell Therapy (GETH). Plerixafor was administered subcutaneously to 30 HRDs at a median dose of 0.24 mg/Kg (interquartile range (IQR): 0.23-0.25) because mobilization failure after using mobilization with G-CSF (mobilization failure was defined as collection of <4.0 ? 106 CD34+ cells/Kg recipient). All HRDs received G-CSF at a median dose of 11 ?g/Kg/day (IQR: 10?12) for 4?5 days. Leukocytapheresis after G-CSF mobilization was performed in 23 (77 %) HRDs collecting a median of 1.6 ? 106 CD34+ cells/Kg recipient weight (IQR: 0.9?2.5). Addition of plerixafor allowed the collection of a higher median number of CD34 cells (4.98 ? 106 CD34+ cells/Kg recipient weight (IQR: 3.5?5.8)) when compared with the collection of CD34+ cells with G-CSF alone (p < 0.01). The final median total number of CD34+ cells collected was 6.1 ? 106/Kg recipient weight (IQR: 4.8?7.3). Mild adverse events related with plerixafor administration were reported in 8 (27 %) donors. In conclusion, addition of plerixafor after G-CSF mobilization failure in HRDs allowed collecting higher number of CD34+ cells in comparison with steady-state mobilization.
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