期刊
TOXICOLOGIC PATHOLOGY
卷 49, 期 4, 页码 905-911出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623320981560
关键词
digital pathology; whole slide imaging; image analysis; artificial intelligence; deep learning; machine learning; bone marrow; cellularity
The study demonstrates the potential of AI tools to provide diagnostic support for toxicologic pathologists in evaluating bone marrow cellularity. The AI model can effectively identify and enumerate bone marrow hematopoietic cells, aiding in research on decreased hematopoietic cellularity severity.
Many compounds affect the cellularity of hematolymphoid organs including bone marrow. Toxicologic pathologists are tasked with their evaluation as part of safety studies. An artificial intelligence (AI) tool could provide diagnostic support for the pathologist. We looked at the ability of a deep-learning AI model to evaluate whole slide images of macaque sternebrae to identify and enumerate bone marrow hematopoietic cells. The AI model was trained and able to differentiate the hematopoietic cells from the other sternebrae tissues. We compared the model to severity scores in a study with decreased hematopoietic cellularity. The mean cells/mm(2) from the model was lower for each increase in severity score. The AI model was trained by 1 pathologist, providing proof of concept that AI model generation can be fast and agile, without the need of a cross disciplinary team and significant effort. We see great potential for the role of AI-based bone marrow screening.
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