期刊
TOXICOLOGIC PATHOLOGY
卷 49, 期 4, 页码 750-754出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0192623320983252
关键词
whole slide image; digital pathology; peer review
This study demonstrated that assessment of whole slide images (WSI) can elicit concordant results to the findings generated from glass slides, showing equivalence between WSI and glass slides for the study.
This Proof of Concept (POC) study was to assess whether assessment of whole slide images (WSI) of the 2 target tissues for a contemporaneous peer review can elicit concordant results to the findings generated by the Study Pathologist from the glass slides. Well-focused WSI of liver and spleen from 4 groups of mice, that had previously been diagnosed to be the target tissues by an experienced veterinary toxicologic pathologist examining glass slides, were independently reviewed by 3 veterinary pathologists with varying experience in assessment of WSIs. Diagnostic discrepancies were then reviewed by an experienced adjudicating pathologist. Assessment of microscopic findings using WSI showed concordance with the glass slides, with only slight discrepancy in severity grades noted. None of the lesions recorded by the Study pathologist were missed and no lesions were added by the pathologists evaluating WSIs, thus demonstrating equivalence of the WSI to glass slides for this study.
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