期刊
TISSUE ENGINEERING PART B-REVIEWS
卷 27, 期 6, 页码 604-626出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.teb.2020.0208
关键词
polysaccharides; tissue engineering; scaffolds; biological property; crosslinking mechanism; modification
类别
资金
- ShenzhenHong Kong Innovation Circle Category D Project [SGDX2019081623180779]
- Shenzhen Science and Technology Innovation Commission, China
- National Natural Science Foundation of China [NSFC51973180]
- Natural Science Foundation for Young Scientists of Jiangsu Province, China [BK20190903]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [19KJB430043]
- City University of Hong Kong [9380099, 9240013, 9680269, 9678192, 7005212]
Polysaccharides are considered promising biomaterials for tissue engineering due to their significant bioactivities, natural abundance, immunoactivity, and chemical modifiability. They have unique biological properties compared to synthetic materials and have garnered attention in academia and industry. By modifying functional groups on the surface of polysaccharide molecules, remarkable mechanical properties and tunable tissue response can be achieved.
Impact statement Polysaccharides are promising biomaterials due to their significant bioactivities, natural abundance, immunoactivity, and chemical modifiability for tissue engineering (TE) applications. As an important natural macromolecule, polysaccharide has attracted much attention both in academia and industry for several biomedical applications. Compared with synthetic materials, polysaccharides have unique biological properties; it is self-evident that polysaccharides will always be the research hotspot in fabricating various biomaterials for different TE. However, most researches about polysaccharides-based materials are still far from practical treatment. This review summarizes the main essential properties of polysaccharides, providing the basic information about chemical properties, crosslinking mechanisms, and biological properties. Recent researches about design and fabrication of polysaccharides-based materials are summarized. In addition to proteins and nucleic acids, polysaccharides are an important type of biomacromolecule widely distributed in plants, animals, and microorganisms. Polysaccharides are considered as promising biomaterials due to their significant bioactivities, natural abundance, immunoactivity, and chemical modifiability for tissue engineering (TE) applications. Due to the similarities of the biochemical properties of polysaccharides and the extracellular matrix of human bodies, polysaccharides are increasingly recognized and accepted. Furthermore, the degradation behavior of these macromolecules is generally nontoxic. Certain delicate properties, such as remarkable mechanical properties and tunable tissue response, can be obtained by modifying the functional groups on the surface of polysaccharide molecules. The applications of polysaccharide-based biomaterials in the TE field have been growing intensively in recent decades, for example, bone/cartilage regeneration, cardiac regeneration, neural regeneration, and skin regeneration. This review summarizes the main essential properties of polysaccharides, including their chemical properties, crosslinking mechanisms, and biological properties, and focuses on the association between their structures and properties. The recent progress in polysaccharide-based biomaterials in various TE applications is reviewed, and the prospects for future studies are addressed as well. We intend this review to offer a comprehensive understanding of and inspiration for the research and development of polysaccharide-based materials in TE.
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