期刊
TEXTILE RESEARCH JOURNAL
卷 91, 期 9-10, 页码 1146-1154出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0040517520975622
关键词
silk fibroin; hierarchical structures; mechanical properties; biodegradable film
资金
- National Key R&D Program of China [2016YFC0802802]
- NUS AcRF Tier 1 [R144-000-367-114]
- 111'' project [B16029]
- National Nature Science Foundation of China [U1405226, 51502253, 21503175, 21705135]
- China Scholarship Council
Blending polyethylene glycol into silk fibroin solutions can reconstruct the hierarchical micro structure and improve the mechanical performance of the composite film, which is beneficial for cell proliferation and adhesion.
Silk fibroin (SF) material receives a great deal of attention in the biomedical field for its extensive mechanical performance and applications due to its singular structure/properties and applications, especially hierarchical structure. Here, we blended polyethylene glycol (PEG) into SF solutions that reconstruct the hierarchical micro structure of SF. The effect of PEG on the SF gelation process was in situ observed through rheological measurement and optical density changes. The structural change of SF/PEG blended films with different concentrations and their effects on the mechanical performance were investigated. The results indicated that with increasing PEG content, the beta-sheet content of the films increased with the alpha-helix declining, which enables a composite film with a fracture strain exceeding 300%, Young's modulus exceeding 200 MPa and a fracture strength exceeding 20 MPa. The culture of MC-3T3 proves that the film is beneficial for cell proliferation and adhesion. By constructing the mesoscopic structure of SF, the plasticized silk materials provide great options for biodegradable and flexible protein-based materials.
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