期刊
TETRAHEDRON LETTERS
卷 65, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2020.152754
关键词
L-proline; Green chemistry; Pyrazolo pyranopyrimidine; Four-component reaction; Multicomponent reactions (MCR)
资金
- Pukyong National University
An efficient synthetic protocol for the preparation of pyrano pyrimidine carboxylate derivatives via a one pot four-component reaction catalyzed by L-Proline has been developed. This methodology offers high yields, operational simplicity, and a greener approach by avoiding toxic catalysts and hazardous solvents.
A simple and efficient synthetic protocol for the synthesis of methyl 4-(4-chlorophenyl)-5,7-dioxo-1-phenyl-1,4,5,6,7,8-hexahydropyrazolo [4',3]:5,6] pyrano[2,3-d] pyrimidine-3-carboxylate derivatives via a one pot four-component reaction catalyzed by L-Proline has been successfully developed. This new protocol produces pyrano pyrimidine carboxylate derivatives in good to excellent yields, with operational simplicity. The remarkable features of this methodology are high yields, metal-free catalyst, easy work-up procedure, and a greener method that avoids toxic catalyst and hazardous solvents. (C) 2021 Elsevier Ltd. All rights reserved.
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