Mukaiyama's reagent promoted mild protocol for one-pot metal-free synthesis of dihydro quinazolinones

We have developed a fast and convenient method to prepare dihydroquinazolin-4(1H)-ones from anthranilamide and different aromatic aldehydes by using the Mukaiyama reagent. The reactions proceeded smoothly with a broad scope of substrates providing the expected products in good to excellent yields under with a low environmental factor and high atom economy. The metal-free condition and the ease of product isolation are the highlighted advantages in solving the issue of trace metal contamination in synthesized pharmaceuticals. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

A new method has been developed for the preparation of dihydroquinazolin-4(1H)-ones from anthranilamide and aromatic aldehydes using the Mukaiyama reagent. The reactions proceed smoothly with high yields, low environmental impact, and high atom economy. The metal-free condition and ease of product isolation are highlighted advantages in addressing trace metal contamination in synthesized pharmaceuticals.