Efficient C3-alkylsulfenylation of indoles under mild conditions using Lewis acid-activated 8-quinolinethiosulfonates

The activation of 8-quinolinethiosulfonates by zinc chloride promotes the usually difficult to achieve C3-alkylsulfenylation of indoles at room temperature under aerobic conditions. This strategy is compatible with substrates containing various functional groups. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

The activation of 8-quinolinethiosulfonates by zinc chloride enables the C3-alkylsulfenylation of indoles at room temperature under aerobic conditions, which is compatible with substrates containing various functional groups.