期刊
TETRAHEDRON LETTERS
卷 63, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2020.152719
关键词
Amidation; Amines; Carboxylic acids; EDC; HOBt; DMAP
资金
- National Institutes of Health [AI150466]
- Purdue University Center for Cancer Research
The study presents a convenient protocol for amide bond formation, suitable for electron deficient amines and carboxylic acids, enabling the synthesis of a variety of functionalized amide derivatives.
A convenient protocol for amide bond formation for electron deficient amines and carboxylic acids is described. Amide coupling of aniline derivatives has been investigated with a number of reagents under a variety of reaction conditions. The use of 1 equivalent of EDC and 1 equivalent of DMAP, catalytic amount of HOBt and DIPEA provided the best results. This method is applicable for the synthesis of a range of functionalized amide derivatives with electron deficient and unreactive amines. (C) 2020 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据