An efficient synthesis of diimidazo[1,2-a:1′,2′-c]quinazolines via a copper-catalyzed double Ullmann cross-coupling reaction

2,3-Bisaryldiimidazo [1,2-a:1',2'-c]quinazolines were obtained via a copper-catalyzed reaction between 2-(2-bromophenyl)-4,5-diphenyl-1H-imidazole and 2-bromo-1H- imidazole in good yields. This double Ullmann cross-coupling built two new Csp(2)-N bonds and fused tetracyclic heterocycle bearing four nitrogen atoms in one-pot procedure. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

2,3-Bisaryldiimidazo [1,2-a:1',2'-c]quinazolines were successfully synthesized via a copper-catalyzed reaction, with good yields. This reaction employed a double Ullmann cross-coupling to build two new Csp(2)-N bonds in one-pot procedure, resulting in the formation of a tetracyclic heterocycle bearing four nitrogen atoms.