期刊
TETRAHEDRON
卷 83, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2021.131961
关键词
Normorphan; Vinyl MIDA boronate; Building block; Medicinal chemistry; Lead-like compounds
资金
- Royal Society (Industry Fellowship)
- EPSRC Impact Accelerator Account (IAA)
- Higher Education Innovation Fund (HEIF)
- Royal Society (AstraZeneca) [INF\R1\191028]
A novel, bifunctional molecule with various functional handles for synthetic manipulation has been developed and commercialized for purchase. The library of compounds derived from this building block has attractive lead-like properties.
A multi-gram-scale synthetic route to a novel, bifunctional normorphan 3D building block bearing orthogonally reactive vinyl MIDA boronate and N-2,4-dimethoxybenzyl (DMB) amide functional handles has been developed. Synthetic manipulation at each of the functional handles has been demonstrated including Suzuki-Miyaura cross-coupling, exo-diastereoselective hydrogenation, N-DMB group removal and lactam reduction. Normorphan cores derived from the building block satisfied AstraZeneca's 'rule of 2' for building blocks and had a high fraction of sp(3) hybridised carbon atoms (Fsp(3)). A virtual lead-like library of 344 compounds derived from the building block had attractive lead-like properties. The 3D building block has been commercialised by Redbrick Molecular and is currently available for purchase. (C) 2021 Elsevier Ltd. All rights reserved.
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