期刊
TETRAHEDRON
卷 79, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2020.131826
关键词
L-proline dihydrazides; N-oxide ligands; Copper catalysis; C-N bond formation; C-O bond formation
资金
- National Natural Science Foundation of China [21702026]
- Fundamental Research Funds for the Central Universities [N2005004, N180705004]
A novel catalytic system based on L-proline N-oxide/CuI was developed and successfully applied to cross-coupling reactions of various N- and O- nucleophilic reagents with aryl iodides and bromides, achieving high yields of up to 99% in synthesizing a variety of products.
A novel catalytic system based on L-proline N-oxide/CuI was developed and applied to the cross-coupling reactions of various N- and O- nucleophilic reagents with aryl iodides and bromides. This strategy featured in the employment of an L-proline derived dihydrazides N-oxide compound as the superior supporting ligand. By using this protocol, a variety of products, including N-arylimidazoles, N-arylpyrazoles, N-arylpyrroles, N-arylamines, and aryl ethers, were synthesized with up to 99% yield. (C) 2020 Elsevier Ltd. All rights reserved.
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