Synthesis of indole-fused scaffolds via [3+3] cyclization reaction of 2-indolylmethanols with quinone imines

A formal [3 + 3] cyclization reaction of 2-indolylmethanols with quinones was realized to furnish indole-fused scaffolds in moderate to excellent yields. This protocol was proceeded smoothly under acid condition, with high high yields and broad substrate scope. (C) 2020 Elsevier Ltd. All rights reserved.

Automated summary

A formal [3 + 3] cyclization reaction between 2-indolylmethanols and quinones was achieved, resulting in the formation of indole-fused scaffolds with moderate to excellent yields. The protocol proceeded smoothly under acidic conditions, showing high yields and a broad substrate scope.