期刊
TETRAHEDRON
卷 80, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2020.131863
关键词
Enamine hydrogenation; Electronic effects; Enantioselective hydrogenation; Planar chirality; Deuterium labelling
资金
- University of St Andrews (UK)
- EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT) [EP/L016419/1]
- Dr Reddy's Laboratories (EU Ltd.)
The asymmetric hydrogenation of enamines is efficiently catalyzed by a rhodium catalyst complexed with a fluorinated planar chiral paracyclophane-diphosphine ligand, showing high activity. This catalyst has also been successfully applied to Direct Asymmetric Reductive Amination, producing several tertiary amines with moderate enantioselectivity.
An asymmetric hydrogenation of enamines is efficiently catalysed by rhodium complexed with a fluorinated version of the planar chiral paracyclophane-diphosphine ligand, Phanephos. This catalyst was shown to be very active, with examples operating at just 0.1 mol% of catalyst. This catalyst was then successfully adapted to Direct Asymmetric Reductive Amination, leading to the formation of several tertiary amines with moderate ee, if activated ketone/amine partners are used. (C) 2020 Elsevier Ltd. All rights reserved.
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