Phosphine-catalyzed stereoselective dimerizations of ketenes

Full details of optimisation studies of the phosphine-catalyzed ketene homodimerization reaction and the detailed development of an asymmetric variant are discussed. Studies towards the development of a phosphine-catalyzed ketene heterodimerization reaction are revealed. A discussion of possible reaction mechanisms for the dimerization reactions, supported by spectroscopic analysis of intermediates and trapping experiments, is also presented. (C) 2020 The Author(s). Published by Elsevier Ltd.

Automated summary

This article discusses the full details of optimization studies of the phosphine-catalyzed ketene homodimerization reaction and the development of an asymmetric variant. It also reveals studies towards the development of a phosphine-catalyzed ketene heterodimerization reaction, and includes a discussion of possible reaction mechanisms supported by spectroscopic analysis of intermediates and trapping experiments.