Iron-catalyzed benzylic addition of 2-methyl azaarenes to substituted trifluoromethyl ketones

This paper demonstrated a new and economical methodology using Fe(ClO4)(2)center dot H2O as a catalyst for the direct C(sp(3))-H functionalization of 2-methyl azaarenes via addition to trifluoromethyl ketones. The use of Fe salts as a Lewis acid catalyst has shown great potential as an accessible, affordable, and effective catalyst for the reaction. Under mild, optimized conditions, an extensive range of 2-alkenylated azaarenes was produced with yields of up to 95%.

Automated summary

This paper demonstrated a new and economical methodology using Fe(ClO4)(2)center dot H2O as a catalyst for the direct C(sp(3))-H functionalization of 2-methyl azaarenes via addition to trifluoromethyl ketones. The use of Fe salts as a Lewis acid catalyst has shown great potential as an accessible, affordable, and effective catalyst for the reaction. Under mild, optimized conditions, an extensive range of 2-alkenylated azaarenes was produced with yields of up to 95%.