A new method for the synthesis of chalcone derivatives promoted by PPh3/I2under non-alkaline conditions

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I-2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

Automated summary

The method developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in non-strongly alkaline conditions significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions. It is a straightforward and general method that shows promise for the synthesis of a variety of chalcone derivatives.