期刊
SYNTHETIC COMMUNICATIONS
卷 51, 期 4, 页码 625-634出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00397911.2020.1847295
关键词
Aldehyde; chalcone; Claisen-Schmidt reaction; ketone; PPh3; I2
资金
- Special Fund for Strategic Pilot Technology of the Chinese Academy of Sciences [XDA12020379]
- National Natural Science Foundation of China [81973455]
- National Key R&D Program of China [2018YFC1707900]
The method developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in non-strongly alkaline conditions significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions. It is a straightforward and general method that shows promise for the synthesis of a variety of chalcone derivatives.
A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I-2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.
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