期刊
SYNTHESIS-STUTTGART
卷 53, 期 7, 页码 1331-1340出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1706599
关键词
pyrrolidine spirocycles; 1,3-dipolar cycloaddition; azomethine ylides; stereogenic centers; copper; GanPhos
资金
- National Natural Science Foundation of China [21702189]
- Key Scientific and Technological Project of Henan Province [202102310004]
- China Postdoctoral Science Foundation [2017M610458, 2018T110737]
- Henan University of Engineering of China
A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cycloaddition of azomethine ylides is reported in this study, providing optically active spiro[dihydronaphthalene-2,3'-pyrrolidine]s with one spiro quaternary and three tertiary stereogenic centers in good yields and high ee values. This protocol demonstrates high diastereo- and enantioselectivity, broad substrate scope, and mild reaction conditions.
A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cycloaddition of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3'-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- and enantioselectivity, broad substrate scope and mild reaction conditions.
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