Development of a Novel Method for Trimethylsilylation of Saccharides

The trimethylsilyl (TMS) group is widely used in carbo-hydrate synthesis, although this protecting group is unstable and its post-synthetic purification challenging. The successful trimethylsilyl-ation of carbohydrates mediated by recyclable and efficient acidic catalyst PTA/HMDS and the novel reagent, TMSOAc (TEA/TMSOAc), under alkaline condition is reported. The advantages of these methods are that the reactions proceed in good to excellent yields without applying column chromatography for purification.

Automated summary

This method reports the successful trimethylsilylation of carbohydrates under alkaline conditions using recyclable and efficient acidic catalyst PTA/HMDS and the novel reagent TMSOAc (TEA/TMSOAc). Unlike traditional methods, these reactions proceed in good to excellent yields without requiring column chromatography for purification.