Controllable Lewis Base Catalyzed Michael Addition of α-Aminonitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams

A novel protocol for the synthesis of functionalized gamma-amino acid esters and gamma-lactams through a controllable Lewis base catalyzed Michael addition of alpha-aminonitriles to simple activated alkenes has been developed. The scope, versatility, and efficiency of the process were demonstrated.

Automated summary

A novel protocol for the synthesis of functionalized gamma-amino acid esters and gamma-lactams through a controllable Lewis base catalyzed Michael addition of alpha-aminonitriles to simple activated alkenes has been developed, demonstrating the scope, versatility, and efficiency of the process.