Vitamin B12-Catalyzed Dicarbofunctionalization of Bromoalkenes Under Visible Light Irradiation

Vitamin B-12 plays a crucial role in enzymatic transformations. This natural compound proved also useful as a catalyst in numerous organic reactions. Commercial availability and lower cost than precious metal complexes, make cobalamin an attractive candidate for a broader use as a benign Co-catalyst. Herein, the vitamin B-12-catalyzed dicarbofuntionalization of bromoalkenes with electrophilic olefins is reported leading to substituted pyrrolidines and piperidines in decent yields after only 15 minutes under light irradiation.

Automated summary

Vitamin B-12 plays a crucial role as a catalyst in organic reactions, facilitating the dicarbofuntionalization of bromoalkenes with electrophilic olefins to yield substituted pyrrolidines and piperidines efficiently.