Transient- and Native-Directing-Group-Enabled Enantioselective C-H Functionalization

In recent years, transition-metal-catalyzed enantioselective C-H bond functionalization using chiral transient directing groups (cTDGs) or native directing groups (NDGs) has emerged as a powerful and attractive- synthetic approach to streamline the synthesis of chiral molecules-. This short review focuses on recent advances on imine-based cTDGs strategies and native amine and carboxylic acid directed strategies for the asymmetric functionalization of various C-H bonds. We have endeavored to highlight the great potential of this methodology and hope that this review will inspire further research in this area.

Automated summary

This short review focuses on recent advances in utilizing cTDGs and NDGs for the synthesis of chiral molecules, highlighting the potential of this method and hoping to inspire further research in this area.