期刊
SYNLETT
卷 32, 期 7, 页码 708-712出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1706682
关键词
antibacterial activity; base catalysts; quinolines; indoline; multistep synthesis
A convenient synthesis method has been designed for the preparation of novel aminoquinoline derivatives, which have been characterized and evaluated for their antibacterial activities against human pathogenic bacteria.
A convenient synthesis of 2 '-amino-7 ',7 '-dimethyl-2,5 '-dioxo-1 '-(phenylamino)-5 ',6 ',7 ',8 '-tetrahydro-1 ' H-spiro[indoline-3,4 '-quinoline]-3 '-carbonitrile derivatives has been designed using different substituted isatins, various 5,5-dimethyl-3-(2-phenylhydrazinyl)cyclohex-2-enones (arylhydrazones of dimedone) and malononitrile in ethanol with piperidine as catalyst at room temperature. The structures of the synthesized compounds have been elucidated by various spectroscopic techniques. The selected compounds have also been evaluated for their antibacterial activities against human pathogenic bacteria.
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