期刊
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
卷 99, 期 4, 页码 351-362出版社
KARGER
DOI: 10.1159/000512599
关键词
Dystonia; Globus pallidus; Basal ganglia; Magnetic resonance imaging; Volumetry
The pathophysiology of dystonia remains poorly understood. Differences in brain structure were observed in primary dystonia patients compared to controls, particularly in young patients. T2 hyperintensive signal alterations in the globus pallidus may indicate overactivity, but their pathogenic role remains unclear.
Objective: The pathophysiology of dystonia is poorly understood. As opposed to secondary forms of dystonia, primary dystonia has long been believed to lack any neuroanatomical substrate. During trajectory planning for DBS, however, conspicuous T2-hyperinstensive signal alterations (SA) were registered within the target region, even in young patients, where ischemia is rare. Methods: Fifty MRIs of primary dystonia patients scheduled for DBS were analyzed. Total basal ganglia (BG) volumes, as well as proportionate SA volumes, were measured and compared to 50 age-matched control patients. Results: There was a 10-fold preponderance of percentaged SA within the globus pallidus (GP) in dystonia patients. The greatest disparity was in young patients <25 years. Also, total BG volume differences were observed with larger GP and markedly smaller putamen and caudate in the dystonia group. Conclusions: BG morphology in primary dystonia differed from a control population. Volume reductions of the putamen and caudate may reflect functional degeneration, while volume increases of the GP may indicate overactivity. T2-hyperintensive SA in the GP of young primary dystonia patients, where microvascular lesions are highly unlikely, are striking. Their pathogenic role remains unclear. (c) 2021 The Author(s). Published by S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据