期刊
STEM CELL RESEARCH
卷 49, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scr.2020.102081
关键词
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资金
- Swedish Research Council [2015-02424]
- AstraZeneca
- Hjarnfonden [FO2019-0210, FO2020-0171]
- Science for Life Laboratory
- Savstaholm Society
Down syndrome (DS) is caused by trisomy for chromosome 21 (T21). We generated two induced pluripotent stem cell (iPSC) lines from skin fibroblasts of two males with DS using Sendai virus delivery of OCT4, SOX2, KLF4, and c-MYC. Characterization of the two iPSC lines, UUIGPi013-A and UUIPGi014-A, showed that they are genetically stable with a 47,XY,+21 karyotype. Both lines displayed expression of pluripotency markers and trilineage differentiation capacity. These two iPSC lines provide a useful resource for DS modeling and pharmacological interventions.
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