4.8 Article

Regulating Catalytic Activity of DNA-Templated Silver Nanoclusters Based on their Differential Interactions with DNA Structures and Stimuli-Responsive Structural Transition

期刊

SMALL
卷 17, 期 3, 页码 -

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202006553

关键词

catalytic activity; DNAs; reversible regulation; silver nanoclusters; structural transition

资金

  1. National Natural Science Foundation of China [21427811, 21721003, 22004119]
  2. National Key Research & Development Plan Grant [2016YFA0203200]

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This work demonstrates exquisite engineering of catalytic activity of DNA-templated silver nanoclusters (DNA-AgNCs) through unique adsorption phenomena of DNAs on DNA-AgNCs and reversible transition between double and triple-stranded DNAs. The study shows that the catalytic activity of DNA-AgNCs can be reversibly regulated by controlling the types of polymers and DNA structures.
This work reports exquisite engineering of catalytic activity of DNA-templated silver nanoclusters (DNA-AgNCs) based on unique adsorption phenomena of DNAs on DNA-AgNCs and reversible transition between double and triple-stranded DNAs. Four DNA homopolymers exhibit different inhibition effects on the catalytic activity of DNA-AgNCs, poly adenine (polyA) > poly guanine (polyG) > poly cytosine (polyC) > poly thymine (polyT), demonstrating that polyA strands have the strongest adsorption affinity on DNA-AgNCs. Through the formation of T-A center dot T triplex DNAs, catalytic activity of DNA-AgNCs is restored from the deactivated state by double or single-stranded DNAs, indicating the participation of N7 groups of adenine bases in binding to DNA-AgNCs and blocking active sites. Accordingly, reversibly regulating catalytic activity of DNA-AgNCs can be realized based on DNA input-stimulated transition between duplex and triplex structures. In the end, two low-cost and facile biosensing methods are presented, which are derived from the activity-switchable platform. It is worthy to anticipate that the DNA-AgNCs with controlled catalytic activity will inspire researchers to devise more functionalized nanocatalysts and contribute to the exploration of intelligent biomedicine in the future.

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