期刊
SLEEP
卷 44, 期 7, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsab017
关键词
sleep; arousal; Drosophila; nAChR; behavioral genetics
资金
- National Natural Science Foundation of China [32061143017]
- National Key Research and Development Program of China [2017YFE0126500]
Sleep and arousal are both crucial for animals, and the neurotransmitter acetylcholine plays an important role in regulating them. Research has shown that different types of ACh receptors in Drosophila control sleep and arousal through distinct mechanisms in different neurons.
Sleep and arousal are both important for animals. The neurotransmitter acetylcholine (ACh) has long been found to promote both sleep and arousal in mammals, an apparent paradox which has also been found to exist in flies, causing much confusion in understanding sleep and arousal. Here, we have systematically studied all 13 ACh receptors (AChRs) in Drosophila to understand mechanisms underlying ACh function in sleep and arousal. We found that exogenous stimuli-induced arousal was decreased in nAChR alpha 3 mutants, whereas sleep was decreased in nAChR alpha 2 and nAChR beta 2 mutants. nAChR alpha 3 functions in dopaminergic neurons to promote exogenous stimuli-induced arousal, whereas nAChR alpha 2 and beta 2 function in octopaminergic neurons to promote sleep. Our studies have revealed that a single transmitter can promote endogenous sleep and exogenous stimuli-induced arousal through distinct receptors in different types of downstream neurons.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据