Fabrication of a new fluorogenic probe for detection of phosgene in solution and vapor phase

A new fluorogenic probe, COUBM (where, COUBM = 3-(1H-benzoimidazol-2-yl)-8-benzothiazol-2-yl-chromen-2-ylideneamine) is designed and synthesized for selective and rapid detection of phosgene both in solution and gas phase. COUBM reacts with phosgene to form a cyclic carbamylated product (COUBM-PHOS) and consequently a sharp increase in fluorescence intensity is observed. The probe is efficiently used to detect phosgene in vapor phase using the COUBM loaded filter paper kit. Theoretical calculation by DFT/B3LYP/6-31+G(d) method is performed to interpret the electronic structure and the probable sensing mechanism of the probe for the detection of phosgene.

Automated summary

The fluorogenic probe COUBM is designed for rapid detection of phosgene in both solution and gas phase. It reacts with phosgene to form a carbamylated product, resulting in a sharp increase in fluorescence intensity. The probe can efficiently detect phosgene in vapor phase using a COUBM loaded filter paper kit, and theoretical calculations are performed to interpret the electronic structure and sensing mechanism.