期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 115, 期 -, 页码 45-53出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2020.12.006
关键词
Manganese homeostasis; Host-pathogen interface; Immunotherapy; Neuroinflammation; Immunological pathways
资金
- National Natural Science Foundation of China [31930057, 31530034, 31570791, 91542205, 31701034]
- National Key Research and Development Program [2018YFA0507802, 2018YFA0507801]
- China Postdoctoral Science Foundation [2018M642414]
Manganese plays an essential role in various biological processes, but excess intake can have harmful effects. Pathogenic microorganisms require manganese for basic biochemical activity and virulence, while hosts use nutritional immunity to sequester manganese to defend against pathogen invasion.
Manganese serves as an indispensable catalytic center and the structural core of various enzymes that participate in a plethora of biological processes, including oxidative phosphorylation, glycosylation, and signal transduction. In pathogenic microorganisms, manganese is required for survival by maintaining basic biochemical activity and virulence; in contrast, the host utilizes a process known as nutritional immunity to sequester manganese from invading pathogens. Recent epidemiological and animal studies have shown that manganese increases the immune response in a wide range of vertebrates, including humans, rodents, birds, and fish. On the other hand, excess manganese can cause neurotoxicity and other detrimental effects. Here, we review recent data illustrating the essential role of manganese homeostasis at the host-pathogen interface and in the host immune system. We also discuss the accumulating body of evidence that manganese modulates various signaling pathways in immune processes. Finally, we discuss the key molecular players involved in manganese's immune regulatory function, as well as the clinical implications with respect to cancer immunotherapy.
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