期刊
SCIENCE SIGNALING
卷 13, 期 663, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.abc6438
关键词
-
资金
- NIH [R01 NS-078792, R01 MH097887, R01 AG 055357]
Ca2+ influx through the L-type Ca2+ channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate beta-adrenergic receptors, cAMP production, and protein kinase A activity to augment Ca2+ influx through Ca(v)1.2 and, consequently, cardiomyocyte contractility. Emerging evidence shows that Ca(v)1.2 is regulated by different mechanisms in cardiomyocytes compared to neurons and vascular smooth muscle cells.
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