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JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
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Crystal Structure of LGR4-Rspo1 Complex INSIGHTS INTO THE DIVERGENT MECHANISMS OF LIGAND RECOGNITION BY LEUCINE-RICH REPEAT G-PROTEIN-COUPLED RECEPTORS (LGRs)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma
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RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling
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Structural basis for R-spondin recognition by LGR4/5/6 receptors
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PLOS ONE (2013)
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STRUCTURE (2013)
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NATURE COMMUNICATIONS (2013)
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CELL REPORTS (2013)
LGR5 Interacts and Cointernalizes with Wnt Receptors To Modulate Wnt/β-Catenin Signaling
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Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo
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EMBO REPORTS (2011)
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling
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EMBO REPORTS (2011)
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
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LGR5 Is a Negative Regulator of Tumourigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines
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PLOS ONE (2011)
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
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Proximity ligation assays for sensitive and specific protein analyses
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CELL (2004)