期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 767, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2021.145124
关键词
COVID-19 surveillance; Epidemic early warning; Wastewater-based epidemiology; Fecal shedding; Virus genome recovery
资金
- Japan Agency for Medical Research and Development (AMED) [JPwm0125001]
Wastewater-based epidemiology (WBE) is an important tool in the early warning system for COVID-19 pandemic, with the shedding dynamics of infected individuals and back-calculation of observed viral load being major bottlenecks. Optimal sampling strategy is crucial for the success of WBE projects.
An effective early warning tool is of great administrative and social significance to the containment and control of an epidemic. Facing the unprecedented global public health crisis caused by COVID-19, wastewater-based epidemiology (WBE) has been given high expectations as a promising surveillance complement to clinical testing which had been plagued by limited capacity and turnaround time. In particular, recent studies have highlighted the role WBE may play in being a part of the early warning system. In this study, we briefly discussed the basics of the concept, the benefits and critical points of such an application, the challenges faced by the scientific community, the progress made so far, and what awaits to be addressed by future studies to make the concept work. We identified that the shedding dynamics of infected individuals, especially in the form of a mathematical shedding model, and the back-calculation of the number of active shedders from observed viral load are the major bottlenecks of WBE application in the COVID-19 pandemic that deserve more attention, and the sampling strategy (location, timing, and interval) needs to be optimized to fit the purpose and scope of the WBE project. (C) 2021 The Author(s). Published by Elsevier B.V.
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