The Development of a Method for the Preparative Separation of Salbutamol Enantiomers by Supercritical Fluid Chromatography

This work presents the results of scaling up an analytical technique for supercritical chiral separation of salbutamol to a preparative scale. Chromatographic conditions are determined, and a technique for the preparative separation of the enantiomers by supercritical fluid chromatography is developed, in which the concentration of the R-isomer of salbutamol (enantiomeric purity) is not less than 90% and the yield of the target product is more than 30%.