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Mattia Maroso et al.
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Shahaf Peleg et al.
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Aron Gyuris et al.
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Tania L. Roth et al.
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Anthony Wynshaw-Boris
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Enyuan Shang et al.
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Sung-Wuk Jang et al.
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
Shaun M. Purcell et al.
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Ji-Song Guan et al.
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Shared genetics of bipolar disorder and schizophrenia
James B. Potash et al.
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BinQuan Zhuang et al.
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Nancy C. Andreasen et al.
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Veronique Planchamp et al.
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Anthony G. Wilson
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Gary LeRoy et al.
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James P. Fawcett et al.
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Carolien G. F. de Kovel et al.
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Gianpiero L. Cavalleri et al.
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Structure and acetyl-lysine recognition of the bromodomain
S. Mujtaba et al.
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Anna L. M. Ferri et al.
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Epigenetic regulation in psychiatric disorders
Nadia Tsankova et al.
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Aberrant localization of importin α1 in hippocampal neurons in Alzheimer disease
Hyoung-gon Lee et al.
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Evidence implicating BRD1 with brain development and susceptibility to both schizophrenia and bipolar affective disorder
J. E. Severinsen et al.
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Association of BRD2 polymorphisms with photoparoxysmal response
Susanne Lorenz et al.
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Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies
G Santpere et al.
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Fyn kinase induces synaptic and cognitive impairments in a Transgenic mouse model of Alzheimer's disease
J Chin et al.
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Seizure-induced changes of mineralocorticoid and glucocorticoid receptors in the hippocampus in seizure sensitive gerbils
IK Hwang et al.
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R Götz et al.
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Genetic dissection of photosensitivity and its relation to idiopathic generalized epilepsy
U Tauer et al.
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R Zhou et al.
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X Huang et al.
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G Raivich et al.
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DX Liu et al.
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AS Brown et al.
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DK Pal et al.
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K Inoue et al.
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R Ouchida et al.
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H Neumann et al.
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M Majdan et al.
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c-Jun and the transcriptional control of neuronal apoptosis
J Ham et al.
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Photosensitivity in juvenile myoclonic epilepsy
R Appleton et al.
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