4.3 Review

CNS implications of COVID-19: a comprehensive review

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Summary: The recent outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 has spread rapidly worldwide. Similar to SARS-CoV, this new coronavirus utilizes ACE2 as an entry point to cells. Growing evidence suggests that COVID-19 patients, particularly those in severe condition, exhibit neurological symptoms, indicating the potential for SARS-CoV-2 to infect and damage neurons in the central nervous system. By studying human neurons derived from pluripotent stem cells, we have demonstrated the expression of ACE2 in human neurons. This highlights the importance of considering the neuro-invasive potential of SARS-CoV-2 as both a contributing factor and a therapeutic target for the severe respiratory symptoms in critical COVID-19 cases.

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Summary: SARS-CoV2 infection can lead to acute and subacute neurological manifestations, such as encephalitis and stroke, and may potentially trigger chronic autoimmune and neurodegenerative disorders. Therefore, performing SARS-CoV2 serology when diagnosing these disorders could be beneficial in the future.

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Summary: This study systematically reviewed 73 cases of GBS associated with COVID-19 reported in publications until July 2020. Most patients developed GBS manifestations after COVID-19 infection, with a majority showing good prognosis, and a male predominance was observed.

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Features of anosmia in COVID-19

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NF-κB and tPA Signaling in Kidney and Other Diseases

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Guillain-Barre syndrome related to COVID-19 infection

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Recent Developments in Microfluidic Technologies for Central Nervous System Targeted Studies

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COVID-19-associated acute necrotizing myelitis

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Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke

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SARS-CoV-2 Encephalitis in a 20-year old Healthy Female

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SARS-CoV-2 targets neurons of 3D human brain organoids

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Isolated sudden onset anosmia in COVID-19 infection. A novel syndrome?

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Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms

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