Enhancement of Schiff base biological efficacy by metal coordination and introduction of metallic compounds as anticovid candidates: a simple overview

In the prevailing apocalyptic times of coronavirus disease (COVID-19), the whole scientific community is busy in designing anticovid drug or vaccine. Under such a fascination, Schiff bases or azomethine compounds are continuously interrogated for antimicrobial properties. These compounds represent interesting molecular scaffolds of huge medicinal and industrial relevance. In order to update the current literature support of such facts this article introduces the synthetic chemistry, mechanism of formation of a Schiff base, followed by biological efficacy and finally a suitable discussion on the mechanism of respective bioactivity. In most of the studies revealing the biological evaluation of azomethine functionalized frameworks, fascinated results have been recorded in case of azomethine-metal complexes as compared with the free ligands. Also, the CH=N or C=N form of organic ligands have indicated marvellous results. Therefore, in connection with the biological relevance and microbicidal implications of such metallic compounds, this works reviews the current update of microorganism fighting efficacy of azomethine metal complexes along with the introduction of some metallodrugs as excellent candidates having COVID-19 defending potentiality.

Automated summary

In the current COVID-19 pandemic, the scientific community is focusing on designing antiviral drugs and vaccines, with Schiff bases or azomethine compounds showing promising medicinal and industrial relevance. Studies have indicated that azomethine-metal complexes exhibit superior antimicrobial properties compared to free ligands, suggesting potential for developing new antiviral treatments against COVID-19.