4.7 Article

In vivo fluorescence imaging for Cu2+ in live mice by a new NIR fluorescent sensor

期刊

DYES AND PIGMENTS
卷 130, 期 -, 页码 116-121

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2016.03.017

关键词

Near infrared; Copper ions; Fluorescence imaging; Cell; Mice

资金

  1. National Basic Research Program of China [2015CB856300]
  2. National Natural Science Foundation of China [21271100, 21571099, 10979019]
  3. Natural Science Foundation of Jiangsu Province [BK20150054]

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Modifying the BODIPY fluorophore with a 4-aminostyryl group forms a NIR fluorescent Cu2+ sensor with a large Stokes shift, high photostability and a high quantum yield. The in vivo Cu2+ fluorescence imaging in live mice was realized for the first time with this sensor, profiting from its reduced self-absorption and minor photobleaching. (C) 2016 Elsevier Ltd. All rights reserved.

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