期刊
REPRODUCTIVE TOXICOLOGY
卷 99, 期 -, 页码 80-95出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2020.11.013
关键词
Perinatal depression; Development; Maternal care; Offspring; SSRI; Anxiety; Depression; Stress; Pregnancy; Maternal interactions; Gene; Environment; Serotonin; Maternal stress; Maternal anxiety
资金
- BC Children's Hospital Research Institute (University of British Columbia)
- Kids Brain Health Network through aDevelopmental Neurosciences Research Training Award
- BC Children's Hospital Research Institute
- Canadian Institutes for Health Research
- l'Institut des Neurosciences Cliniques de Rennes (INCR)
- the Brain Canada
Research has focused on the impact of SSRI and other antidepressants during the perinatal period on anxiety and depression behaviors in offspring, showing varying outcomes influenced by factors such as early exposure timing, gender, maternal stress experimental models, and non-SSRI medications. Additionally, maternal caregiving and gene-environment interactions may also contribute to the effects of perinatal SSRI exposure and maternal mental illness on affective behaviors in children.
The developmental impact of selective serotonin reuptake inhibitor (SSRI) and other antidepressant treatments during gestation and postpartum on anxiety and depression behaviors in offspring is unclear. This review focuses on how perinatal exposure to SSRI and other antidepressant may have long term consequences for these affective behaviors during early childhood and beyond. Outcomes vary and consideration is given to methodological factors related to how early SSRI exposure affects developments studied in rodent models such as: a) between pre- and early post-natal SSRI exposure, b) sex, c) experimental models of gestational maternal stress and d) impact of non-SSRI antidepressant medications. We will also review how multiple contextual factors (maternal caregiving and gene x environment interactions) may contribute to the effects of perinatal SSRI exposure and maternal mental illness on affective behaviors in children.
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