期刊
REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷 121, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yrtph.2021.104868
关键词
PFOA; PFOS; PFAS; Human Biomonitoring; HBM-II-value
资金
- Umweltbundesamt (German Environmental Agency), Germany
The Human Biomonitoring Commission of the German Environment Agency develops toxicologically justified assessment values (HBM-I and HBM-II) to evaluate internal exposure to harmful substances, with HBM-I corresponding to no adverse health effects expected and HBM-II indicating potential health impairments. Different HBM-II values are established for various population groups.
For evaluation of internal exposure to harmful substances, the Human Biomonitoring Commission of the German Environment Agency (HBM Commission) develops toxicologically justified assessment values (HBM-I and HBMII). The HBM-I value corresponds to the concentration of a compound in human biological material below which no adverse health effects are expected to occur. Consequently, no action is required when the HBM-I value is not exceeded (HBM-Commission, 1996). In 2016, the HBM Commission developed HBM-I values of 2 ng PFOA/mL and 5 ng PFOS/mL in blood serum or plasma, respectively. A detailed delineation of supporting arguments was published in April 2018 (HBM-Commission, 2018). In contrast to the HBM-I, the HBM-II value corresponds to the concentration in human biological material which, when exceeded, may lead to health impairment which is considered as relevant to exposed individuals (HBM-Commission, 1996, HBM-Commission, 2014). HBM-II values for PFOA and PFOS: On September 17, 2019, the HBM Commission of the German Environment Agency established the following HBM-II values: Women at child-bearing age: 5 ng PFOA/mL blood plasma; 10 ng PFOS/mL blood plasma; All other population groups: 10 ng PFOA/mL blood plasma; 20 ng PFOS/mL blood plasma.
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