期刊
RARE METALS
卷 40, 期 9, 页码 2486-2493出版社
NONFERROUS METALS SOC CHINA
DOI: 10.1007/s12598-020-01620-0
关键词
Superparamagnetic nanoparticles; Fe3O4; Angelica sinensis polysaccharide; Magnetic resonance imaging; Ultralow toxicity
资金
- National Key Research and Development Program of China [2019YFB2005801]
- National Natural Science Foundation of China [51671019, 51731003, 51971024, 51927802, 51971023]
- Beijing Natural Science Foundation Key Program [Z190007]
- Fundamental Research Funds for the Central Universities [FRF-MP-19-004]
Fe3O4@Angelica sinensis polysaccharide nanoparticles were prepared as a potential new MRI contrast agent with high signal intensity in liver imaging, demonstrating good biocompatibility and low toxicity in vivo.
Although iron oxide (Fe3O4) nanoparticles have broad application prospects as magnetic resonance imaging (MRI) contrast agent, their biocompatibility and biotoxicity still need to be improved. In this study, we prepared Fe3O4@Angelica sinensis polysaccharide nanoparticles (Fe3O4@ASP NPs) with a 9 nm Fe3O4 core and ASP as the coating material. The Fe3O4@ASP NPs are superparamagnetic, can be taken up by liver and spleen macrophages in the circulatory system in vivo, and are a good-biocompatibility and low-toxicity transverse relaxation time (T-2) and T-2-star (T-2*) magnetic resonance imaging (MRI) contrast agent for the liver. The cytotoxicity assessment using HeLa cells and the pathological tests in mice validate that Fe3O4@ASP NPs have low toxicity and good biocompatibility in vivo, which can be attributed to the ASP as a natural polysaccharide with good biocompatibility and its function of protecting the liver. Fe3O4@ASP NPs are a potential new MRI contrast agent with high signal intensity in vivo.
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