期刊
RADIATION AND ENVIRONMENTAL BIOPHYSICS
卷 60, 期 1, 页码 125-134出版社
SPRINGER
DOI: 10.1007/s00411-020-00887-2
关键词
Breast cancer; Low kV-IORT; Spherical applicator; Effective energy; Monte Carlo simulation
The study aimed to evaluate the effective energy of X-rays from a bare probe and different applicators for IORT of breast cancer. It was found that applicators can significantly increase X-ray hardness, resulting in an increase in effective energy, and the applicator diameter also affects the X-ray effective energy.
The study reported in the present paper aimed to evaluate the effective energy (E-eff) of X-rays emitted from the surface of a bare X-ray probe and from different spherical applicators with various diameters, which are widely employed for low kV intraoperative radiotherapy (IORT) of breast cancer. A previously validated Monte Carlo model of the INTRABEAM system along with applicator diameters of 1.5-5 cm (with 0.5 cm increments) was employed for this purpose. The results show that the presence of the applicator can considerably harden the X-rays produced by the bare probe so that E-eff increases by a factor of about 2.6. Variations of applicator diameter also affects the X-ray effective energy. Specifically, increasing the applicator diameter from 1.5 to 3 cm and 3.5-5 cm resulted in an increase in the E-eff by 8.8% and 14.6%, respectively. The validity of the calculated E-eff values was confirmed by a reasonable agreement between the obtained probability density distributions (PDDs) for the full X-ray energy spectrum and those for the corresponding single effective energies, for different applicator diameters. The E-eff values obtained for different applicator diameters and the bare probe alone can be used as an alternative for the corresponding full energy spectra, in Monte Carlo-based dosimetry simulations of low-energy therapeutic X-rays, as well as for determining quality conversion factors of any ion chambers employed for low kV-IORT absolute dosimetry.
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