Survival in adult inpatients with COVID-19

Background: The mortality of the coronavirus disease 2019 (COVID-19) pandemic is high, and data regarding its prognosis are scarce. We aimed to assess the survival experience and determining factors in adult inpatients with laboratory-confirmed COVID-19. Methods: We conducted a nationwide and retrospective cohort study. Data from 66,123 individuals were analyzed using the Kaplan-Meier method, and a multivariate Cox proportional hazard regression model was fitted. Results: The 7-day survival was 72.2% and went to 47.6%, 35.0%, and 23.9% on days 15, 21, and 30 of hospital stay, respectively. In the multiple analysis, factors associated with an increased risk of dying were male gender, age, pneumonia at hospital admission, immunosuppression, and personal history of chronic non-communicable diseases. Reduced risk of a fatal outcome was observed among patients with asthma history. Conclusions: To the best of our knowledge, this is the largest study analyzing the survival probability in a large subset of Latin-American adults with COVID-19, in whom the disease burden has been high. Our results contribute to achieving a better understanding of disease evolution. (C) 2020 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

Automated summary

This study is the largest analysis of survival probability among Latin American adults with COVID-19 to date, showing a decreasing trend in survival rate during hospital stay. Factors associated with an increased risk of dying include male gender, age, pneumonia at hospital admission, immunosuppression, and personal history of chronic diseases, while patients with a history of asthma had a reduced risk of fatal outcomes.