期刊
PSYCHOLOGICAL MEDICINE
卷 52, 期 13, 页码 2540-2548出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291720004420
关键词
Dysconnectivity; functional activity; functional MRI; gray matter; schizophrenia; white matter
资金
- Humboldt Foundation's Friedrich Wihelm Bessel Research Award
- National Natural Science Foundation of China [81671664, 81621003, 81820108018, 81901828]
- National Programfor Support of Top-notch Young Professionals [W02070140]
- Fundamental Research Funds for the Central Universities [2018SCUH0011]
- Science and Technology Project of the Health Commission of Sichuan Province [18ZD035]
- Sichuan Science and Technology Program [2019YJ0155]
- 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University [ZYYC08001, ZYJC18020]
The study found that schizophrenia patients showed reductions in white matter functional activity, particularly in the genu of the corpus callosum. Additionally, there were correlations between white matter and gray matter functional activity, as well as white matter microstructure changes. These findings provide valuable evidence for functional alterations in schizophrenia.
Background There is increasing evidence that blood oxygenation level-dependent signaling in white matter (WM) reflects WM functional activity. Whether this activity is altered in schizophrenia remains uncertain, as does whether it is related to established alterations of gray matter (GM) or the microstructure of WM tracts. Methods A total of 153 antipsychotic-naive schizophrenia patients and 153 healthy comparison subjects were assessed by resting-state functional magnetic resonance imaging, diffusion tensor imaging, and high-resolution T1-weighted imaging. We tested for case-control differences in the functional activity of WM, and examined their relation to the functional activity of GM and WM microstructure. The relations between fractional anisotropy (FA) in WM and GM-WM functional synchrony were investigated as well. Then, we examined the associations of identified abnormalities to age, duration of untreated psychosis (DUP), and symptom severity. Results Schizophrenia patients displayed reductions of the amplitude of low-frequency fluctuations (ALFF), GM-WM functional synchrony, and FA in widespread regions. Specifically, the genu of corpus callosum not only had weakening in the synchrony of functional activity but also had reduced ALFF and FA. Positive associations were found between FA and functional synchrony in the genu of corpus callosum as well. No significant association was found between identified abnormalities and DUP, and symptom severity. Conclusions The widespread weakening in the synchrony of functional activity of GM and WM provided novel evidence for functional alterations in schizophrenia. Regarding the WM function as a component of brain systems and investigating its alternation represent a promising direction for future research.
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