4.4 Article

Intestinal gluconeogenesis and protein diet: future directions

期刊

PROCEEDINGS OF THE NUTRITION SOCIETY
卷 80, 期 2, 页码 118-125

出版社

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0029665120007922

关键词

Intestinal gluconeogenesis; Protein diets; Gut– brain axis; Satiety; Insulin sensitivity

资金

  1. Agence Nationale de la Recherche [ANR11-BSV1-016-01]
  2. Fondation pour la Recherche Medicale [Equipe FRM DEB20160334898, DRM20101220448]
  3. Institut Delessert
  4. Institut Bonduelle
  5. Societe Francophone du Diabete

向作者/读者索取更多资源

This review explores the beneficial effects of high-protein diets on health through the characterization of intestinal gluconeogenesis (IGN), highlighting the indirect satiety effects initiated via IGN and portal glucose sensing. The mu-opioid-antagonistic properties of protein digests in the portal vein play a key role in the control of satiety, shedding new light on the mechanisms by which protein diets improve whole-body homeostasis.
High-protein meals and foods are promoted for their beneficial effects on satiety, weight loss and glucose homeostasis. However, the mechanisms involved and the long-term benefits of such diets are still debated. We here review how the characterisation of intestinal gluconeogenesis (IGN) sheds new light on the mechanisms by which protein diets exert their beneficial effects on health. The small intestine is the third organ (in addition to the liver and kidney) contributing to endogenous glucose production via gluconeogenesis. The particularity of glucose produced by the intestine is that it is detected in the portal vein and initiates a nervous signal to the hypothalamic nuclei regulating energy homeostasis. In this context, we demonstrated that protein diets initiate their satiety effects indirectly via IGN and portal glucose sensing. This induction results in the activation of brain areas involved in the regulation of food intake. The mu-opioid-antagonistic properties of protein digests, exerted in the portal vein, are a key link between IGN induction and protein-enriched diet in the control of satiety. From our results, IGN can be proposed as a mandatory link between nutrient sensing and the regulation of whole-body homeostasis. The use of specific mouse models targeting IGN should allow us to identify several metabolic functions that could be controlled by protein diets. This will lead to the characterisation of the mechanisms by which protein diets improve whole-body homeostasis. These data could be the basis of novel nutritional strategies targeting the serious metabolic consequences of both obesity and diabetes.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据