期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2011266118
关键词
hippocampus; replay; place cell; learning; ripple
资金
- Kaken-hi from the Japan Society for the Promotion of Science (JSPS) [19H04897, 17H05939, 20H03545]
- Japan Science and Technology Agency (JST) [JPMJPR1785]
- Advanced Research & Development Programs for Medical Innovation of the Japan Agency for Medical Research and Development (AMED) [1041630]
- JST Exploratory Research for Advanced Technology [JPMJER1801]
- AMED Strategic International Brain Science Research Promotion Program [18dm0307007h0001]
- JSPS Research Fellowship for Young Scientists
- Grants-in-Aid for Scientific Research [20H03545, 19H04897] Funding Source: KAKEN
During the learning process, hippocampal cell ensembles exhibit dynamic changes in replay patterns, incorporating salient locations and reward-related contexts. The directionality of replays gradually varies, including the replay of optimized paths that have never been exploited by the animals, indicating a prioritized replay of significant experiences.
Hippocampal cells are central to spatial and predictive representations, and experience replays by place cells are crucial for learning and memory. Nonetheless, how hippocampal replay patterns dynamically change during the learning process remains to be elucidated. Here, we designed a spatial task in which rats learned a new behavioral trajectory for reward. We found that as rats updated their behavioral strategies for a novel salient location, hippocampal cell ensembles increased theta-sequences and sharp wave ripple-associated synchronous spikes that preferentially replayed salient locations and reward-related contexts in reverse order. The directionality and contents of the replays progressively varied with learning, including an optimized path that had never been exploited by the animals, suggesting prioritized replays of significant experiences on a predictive map. Online feedback blockade of sharp wave ripples during a learning process inhibited stabilizing optimized behavior. These results implicate learning-associated experience replays that act to learn and reinforce specific behavioral strategies.
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