Recent advances in cytotoxicity, cellular uptake and mechanism of action of ruthenium metallodrugs: A review

Due to these limitations of platinum-based drugs, it has now become a challenge for researchers to find out a potential scaffold furnished with indispensable properties like enhanced selectivity (less toxicity) and target specificity. In the past two decades, ruthenium-based scaffolds have become a matter of keen interest to scientist due to their unique properties. So, in this review, we have focused our attention in dealing with the advances in various types of ruthenium complexes in the anticancer application based on their cytotoxicity profiles, cellular uptake, biological targets and mechanism of action. (c) 2020 Elsevier Ltd. All rights reserved.