期刊
DRUG RESISTANCE UPDATES
卷 29, 期 -, 页码 76-89出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2016.10.002
关键词
Antibiotic tolerance; Persisters; Resistance; Chronic infections; Pathogens
资金
- Agency for Innovation by Science and Technology (IWT)
- FWO [G047112N, G0B2515N]
- KU Leuven Research Council [PF/10/010]
- Interuniversity Attraction Poles Program initiated by the Belgian Science Policy Office [IAP P7/28]
Any bacterial population harbors a small number of phenotypic variants that survive exposure to high concentrations of antibiotic. Importantly, these so-called 'persister cells' compromise successful antibiotic therapy of bacterial infections and are thought to contribute to the development of antibiotic resistance. Intriguingly, drug-tolerant persisters have also been identified as a factor underlying failure of chemotherapy in tumor cell populations. Recent studies have begun to unravel the complex molecular mechanisms underlying persister formation and revolve around stress responses and toxin-antitoxin modules. Additionally, in vitro evolution experiments are revealing insights into the evolutionary and adaptive aspects of this phenotype. Furthermore, ever-improving experimental techniques are stimulating efforts to investigate persisters in their natural, infection-associated, in vivo environment. This review summarizes recent insights into the molecular mechanisms of persister formation, explains how persisters complicate antibiotic treatment of infections, and outlines emerging strategies to combat these tolerant cells. (C) 2016 Elsevier Ltd. All rights reserved.
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